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Conjugated bilirubin delivered to the gut from the biliary system is deconjugated by β-glucuronidase and subsequently reduced by intestinal microbiota in the intestinal lumen to bilirubin metabolic compounds including urobilinogen, urobilin, dihydrobilirubin, mesobilirubin, dihyrdomesobilirubin, urobilinogen, half-stercobilinogen, and stercobilinogen which is oxidized to form the feces pigment stercobilin [68]
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In the 2 most common types of primary liver cancer, HCC and cholangiocarcinoma, the Wnt/β-catenin signaling is often hyperactivated and promotes the initiation and progression of tumors 8